Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

INTRODUCTION Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles (12). Infectious agents have been found in the brain and postulated to be involved with AD, but robust evidence of causation has not been established (3). The recent...

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