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    Which of the following is true?

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    1. As the concentration of the drug increases over the therapeutic range, only the bound form of the drug increases.
    2. The bound form is not available for metabolism, but is available for excretion.
    3. Acidic drugs bind to beta globulin and basic drugs bind to albumin.
    4. Binding sites are non-specific and one drug can displace the other.
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