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     EduGorilla 
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    The extent to which ionization of a drug takes place is dependent upon pKa of the drug and the pH of the solution in which the drug is dissolved. Which of the following statements is incorrect?

    Options :-

    1. pKa of a drug is the pH at which the drug is 50% ionised.
    2. Small changes of pH near the pka of a weak acidic drug will not affect its degree of ionisation.
    3. Knowledge of pka of a drug is useful in predicting its behaviour in various body fluids.
    4. Phenobarbitone with pKa of 7.2 is largely unionised at acid pH and will be about 40% non-ionised in plasma.
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