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The Cosmetics Regulation 1223/2009 is the main regulatory framework for finished products when placed on the EU market. Cosmetic products must be safe for human health.

The safety is largely based on the security of the ingredients, and their toxicological profile has to be evaluated.

The determination of the toxicological profile of an ingredient is based on a series of toxicity studies and the major endpoints that may be relevant to assess are eye and skin irritation, skin sensitization, photo-induced toxicity and genotoxicity. For each one, different test methods may be used and, depending on the type of sample,…



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